Shinichi Sakurai, a college junior, desires nothing more than a peaceful existence. However, he spends most of his time with his vivacious and well-endowed junior, Hana Uzaki. Uzaki is concerned that her melancholic senior will endure college just as he did high school, isolated and friendless. To remedy this, she assumes responsibility for making Sakurai's days stimulating by incessantly dragging him around. Unified by their encounters, Uzaki teaches her reserved senior that companionship can be valuable. Although Sakurai finds Uzaki's ceaseless teasing aggravating, he relishes the days spent together, and amusingly, their time ends in comedic misunderstandings. "Uzaki-chan wa Asobitai!" is a slice-of-life narrative that follows the comedic exploits of Sakurai and Uzaki, who oddly enough, despite their entirely different demeanors, develop a charming relationship.